活動報告
抄読会
2025/04/08
発表者:牧之段学
論文情報:Wolf, D., Hartig, R., Zhuo, Y. et al. Oxytocin induces the formation of distinctive cortical representations and cognitions biased toward familiar mice. Nat Commun 15, 6274 (2024).
2025/04/15
発表者:鳥塚通弘
論文情報:O’Keeffe, M., Booker, S.A., Walsh, D. et al. Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus. Nat Neurosci 28, 268–279 (2025).
2025/04/22
発表者:竹田奨
論文情報:Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, Bhaduri A, Goyal N, Rowitch DH, Kriegstein AR. Single-cell genomics identifies cell type-specific molecular changes in autism. Science. 2019 May 17;364(6441):685-689.
2025/05/27
発表者:玉腰広人
論文情報:
2025/06/10
発表者:牧之段学
論文情報:
2025/06/17
発表者:鳥塚通弘
論文情報:Koskuvi M, Pörsti E, Hewitt T, Räsänen N, Wu YC, Trontti K, McQuade A, Kalyanaraman S, Ojansuu I, Vaurio O, Cannon TD, Lönnqvist J, Therman S, Suvisaari J, Kaprio J, Blurton-Jones M, Hovatta I, Lähteenvuo M, Rolova T, Lehtonen Š, Tiihonen J, Koistinaho J. Genetic contribution to microglial activation in schizophrenia. Mol Psychiatry. 2024 Sep;29(9):2622-2633.
2025/06/24
発表者:竹田奨
論文情報:North HF, Weissleder C, Bitar M, Barry G, Fullerton JM, Webster MJ, Weickert CS. RNA-sequencing suggests extracellular matrix and vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated inflammation. Schizophrenia (Heidelb). 2024 May 4;10(1):50. doi: 10.1038/s41537-024-00466-0. PMID: 38704390; PMCID: PMC11069512.
2025/07/08
発表者:玉腰広人
論文情報:Contestabile A, Kojovic N, Casarotto G, Delavari F, Hagmann P, Schaer M, Bellone C. Translational research approach to social orienting deficits in autism: the role of superior colliculus-ventral tegmental pathway. Mol Psychiatry. 2025 Apr 5. doi: 10.1038/s41380-025-02962-w. Epub ahead of print. PMID: 40188311.
2025/07/15
発表者:牧之段学
論文情報:Ju J, Pan Y, Yang X, Li X, Chen J, Wu S, Hou ST. The “don’t eat me” signal CD47 is associated with microglial phagocytosis defects and autism-like behaviors in 16p11.2 deletion mice. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2411080122. doi: 10.1073/pnas.2411080122. Epub 2025 Apr 16. PMID: 40238451; PMCID: PMC12036979.
2025/07/22
発表者:鳥塚通弘
論文情報:Teter OM, McQuade A, Hagan V, Liang W, Dräger NM, Sattler SM, Holmes BB, Castillo VC, Papakis V, Leng K, Boggess S, Nowakowski TJ, Wells J, Kampmann M. CRISPRi-based screen of Autism Spectrum Disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning. bioRxiv [Preprint]. 2024 Nov 17:2024.06.01.596962. doi: 10.1101/2024.06.01.596962. Update in: Mol Psychiatry. 2025 Apr 6. doi: 10.1038/s41380-025-02997-z. PMID: 39605704; PMCID: PMC11601228.
202507/29
発表者:福島 悠太
論文情報:Wu J, Chen X, Zhang J, Wettschurack K, Robinson M, Li W, Zhao Y, Yoo YE, Deming BA, Abeyaratna AD, Que Z, Du D, Tegtmeyer M, Yuan C, Skarnes WC, Rochet JC, Wu LJ, Yang Y. Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation: Microglial diversity and response in assembloids. bioRxiv [Preprint]. 2025 Jun 4:2025.06.04.657874. doi: 10.1101/2025.06.04.657874. PMID: 40501840; PMCID: PMC12157492.